KEY (Early Intervention for Youth At-Risk for Bipolar Disorder)
Principal Investigator: Tina Goldstein, PhD
Co-Investigators: Boris Birmaher MD, Peter Franzen PhD, Danella Hafeman MD PhD, David Kolko PhD, Jessica Levenson PhD
The KEY study is funded by the National Institute of Mental Health (NIMH).
The most potent risk factor for the development of bipolar disorder is a first-degree family member with the illness. Thus, offspring of parents with bipolar disorder are a particularly high-risk group. It is well-established that poor sleep regulation is associated with the onset of depressive and manic episodes among individuals with a biological vulnerability to mood disorder. The proposed study aims to address this core disturbance that we argue puts at-risk youth at even greater risk for development of bipolar disorder—sleep and social rhythm disruption. We had previously conducted 2 treatment development/pilot trials (see Goldstein et al., 2014) to demonstrate the feasibility and acceptability of Interpersonal and Social Rhythm Therapy (IPSRT), an empirically-supported treatment for adults with bipolar disorder that helps patients stabilize sleep/wake cycles and daily routines, for at-risk adolescents. In KEY3, we conducted a pilot randomized trial of the intervention. Data collection for the KEY2 study was completed in May 2015, and data analyses are currently underway.